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Active Ingredients:

  • Metformin

The commercial name of the medication may differ from the brand one. Generic Glucophage manufactured by Mankind Pharma is available under commercial name Metname.

Action mechanism and therapeutic effect of the medication:

Glucophage is a biguanide hypoglycemic agent for oral administration. In patients with diabetes reduces the concentration of glucose in the blood by inhibiting gluconeogenesis in the liver, reducing glucose absorption from the gastrointestinal tract, and enhancing its utilization in the tissues. Glucophage stabilizes or reduces body weight, improves the fibrinolytic characteristic of blood.

Medical indications:

Type 2 diabetes mellitus in adults (including in the ineffectiveness of sulfonylurea), particularly in cases accompanied by obesity

Glucophage contraindications, precautions and warnings:

  • Hypersensitivity, hyperglycemic coma, ketoacidosis, renal insufficiency, liver diseases, heart insufficiency, acute myocardial infarction, respiratory disorders, dehydration
  • Infectious diseases, extensive surgery, trauma
  • Alcoholism, low calorie diet (less than 1000 kcal / day), lactic acidosis (including history), pregnancy, lactation
  • With caution: elderly patients, heavy physical work

Glucophage side effects: As with any other drug, side effects can occur with Metformin. However, it does not mean that everyone who takes the medicine will experience these adverse effects. In most cases the preparation is well tolerated. Metformin may cause the following side effects:

  • Digestive system: nausea, vomiting, metallic taste in the mouth, decreased appetite, indigestion, flatulence, abdominal pain
  • Metabolism: in some cases - lactic acidosis (weakness, myalgia, respiratory disorders, drowsiness, abdominal pain, hypothermia, lowering blood pressure, reflex bradycardia)
  • In long term treatment - hypovitaminosis B12 (malabsorption)
  • Allergic reactions: skin rash

If any side effects occur during the treatment make sure to consult your health care provider immediately. If you are unsure about anything related to Glucophage, please talk to your doctor or pharmacist.

Drug interaction:

Glucophage can potentially interact with the following groups of drugs:

  • diuretics
  • ethanol
  • indirect anticoagulants
  • histamine antagonists
  • other hypoglycemic drugs
  • sulfonylurea medications
  • MAO inhibitors
  • antibiotics
  • ACE inhibitors
  • hypolipidemic agents
  • cytostatics
  • salicylates
  • glucocorticosteroids
  • oral contraceptives
  • hypertensive drugs
  • thyroid gland hormones
  • niacin
  • slow calcium channels blockers

It is possible that all drug interactions are not presented above. For this reason, we recommend you to talk with your health care provide about drug interactions with Metformin which may apply to you.

Additional information for the patients:

The preparation should be taken according to your doctor's recommendations. Never take the drug for conditions which are not presented in the the drug's leaflet. Try to keep the medicine out of the reach of children.